Dimethylamine → HCID 86723837, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-chloro-3-methyl-1-(3-(trifluoromethyl)phenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 56) (301 mg) in isopropyl alcohol (10 ml) was added 50% aqueous dimethyl amine solution (0.5 ml) and the resulting mixture was stirred at 80° C. for two and a half hours. The reaction solutions were concentrated under reduced pressure, and to the residue were added water and methanol, and the resulting mixture was stirred. The precipitated solids were collected by filtration, and washed with water and diethylther to afford 6-(dimethylamino)-3-methyl-1-(3-(trifluoromethyl)phenyl)pyrimidin-2,4(1H,3H)-dione (220 mg).

Provenance & Evidence