Isopropyl iodide → HCID 86723844, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 98 or 99) (135.0 mg) in N,N-dimethy formamide (5.0 ml) were added at room temperature sodium hydride (25.3 mg) and isopropyl iodide (265 μl) and the resulting mixture was stirred at 110° C. for two hours. To the reaction mixture was added saturated aqueous ammonium chloride solution (30.0 ml), and the resulting mixture was extracted with ethyl acetate (20 ml×2) and the organic layer was washed with water (20 ml×2) and saturated saline (20 ml), dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 3-isopropyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (122.5 mg).

Provenance & Evidence