Nitric Acid → HCID 86723852, compound

HRID 576754Notes

Reaction equation

S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[CH:12]=1>>[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[C:12]=1[N+:6]([O-:9])=[O:7]

Participants

Reactant 3

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 867238536-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione

Product 1

HCID 86723852HCID 86723852, compound

Procedure

To concentrated sulfuric acid (2.0 ml) were added in ice bath fuming nitric acid (0.2 ml), 6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 21) (200.0 mg) and the resulting mixture was stirred for three hours in ice bath. The reaction mixture was poured into ice water, and the precipitated solids were collected by filtration to afford 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (219.0 mg).

Workup

filtrationthe precipitated solids were collected by filtration

Sources & evidence

ORD record: ord-28131b9eaba448569b8c88b0db2516e2
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040516B2

Reaction notes

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