HCID 86723852, compound → HCID 86723854, compound

HRID 576755Notes

Reaction equation

HRID 576755 reaction equation
[CH3:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:6](=[O:18])[N:5]([CH2:19][CH2:20][CH3:21])[C:4](=[O:22])[C:3]=1[N+:23]([O-])=O>CO.O.[Pd]>[NH2:23][C:3]1[C:4](=[O:22])[N:5]([CH2:19][CH2:20][CH3:21])[C:6](=[O:18])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=2)[C:2]=1[CH3:1]

Participants

4

Reactant 1

HCID 86723852HCID 86723852, compound

Product 1

HCID 86723854HCID 86723854, compoundYield 103.7%

Reagents, catalysts & solvents 2

HCID 23219155Palladium hydrateCatalystHCID 887MethanolSolvent

Procedure

To a solution of 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (200.0 mg) in methanol (10.0 ml) was added palladium hydrate (20.0 mg) and the resulting mixture was stirred at room temperature under catalytic hydrogenation condition for twelve hours. The reaction mixture was degassed and then filtered through Celite (trade mark), and then concentrated under reduced pressure to afford 5-amino-6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (190.0 mg).

Workup

  1. customThe reaction mixture was degassed
  2. filtrationfiltered through Celite (trade mark)
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-53d5553a1d2845848b6862db8fb1d171
Source dataset
uspto-grants-2015_05
Patent number
US09040516B2

Reaction notes

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