Triphenylphosphine → HCID 86723883, compound

Participants

Reaction Steps

To a solution of 4-(5-(2,4-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-1H-pyrazol-1-yl)benzonitrile (prepared in Example 53) (30 mg) in THF (2 ml) were added tetrahydro-2H-pyran-4-ol (0.014 ml), triphenylphosphine (37 mg) and diethyl azodicarboxylate (2.2 M toluene solution, 0.065 ml) and the resulting mixture was stirred at room temperature for fifteen minutes. The reaction solution was concentrated under reduced pressure and the residue was then purified by silica gel column chromatography (eluent: hexane/ethyl acetate) and reversed phase liquid chromatography (eluent: TFA water/acetonitrile) to afford-4-(5-(2,4-dioxo-3-(tetrahydro-2H-pyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-1H-pyrazol-1-yl)benzonitrile (7 mg).

Provenance & Evidence