反应详情

温度

0 °C

A suspension of the compound prepared in Example 204 (50.0 mg) in acetonitrile (20 ml) was cooled to 0° C. and thereto was added ammonia water (28%, 5.0 ml) dropwise and the mixture was stirred for another ten minutes. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 1-(4-cyanophenyl)-5-(3,6-dimethyl-2,4-dioxo-1-(3-trifluoromethylphenyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-1H-pyrazole-4-sulfonamide (42.0 mg). UPLC/MS 531 (M+H)/0.87 min. (measurement condition 9)

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate)