HCID 59198922, compound → HCID 59198797, compound

HRID 576828Notes

Reaction equation

HRID 576828 reaction equation
[CH:1]1([C:7]2[N:11]3[C:12]4[C:17]([NH:18][C:19](=[O:20])[C:10]3=[CH:9][N:8]=2)=[CH:16][CH:15]=[C:14](/[CH:21]=[CH:22]/[C:23]([O:25][CH3:26])=[O:24])[CH:13]=4)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.[Pd]>[CH:1]1([C:7]2[N:11]3[C:12]4[C:17]([NH:18][C:19](=[O:20])[C:10]3=[CH:9][N:8]=2)=[CH:16][CH:15]=[C:14]([CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])[CH:13]=4)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 59198922HCID 59198922, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59198797HCID 59198797, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
25 °C

Procedure

Methyl(E)-3-(1-cyclohexyl-4-oxo-4,5-dihydroimidazo-[1,5-a]quinoxalin-8-yl)acrylate as synthesized in Example 154, 2.0 g was dissolved in 100 mL of acetic acid, and to the solution 10% Pd/C 200 mg was added in nitrogen atmosphere. After substituting the atmosphere with hydrogen, the reaction liquid was stirred at 25° C. for 2 days. The reaction liquid was filtered through Celite and from the filtrate the solvent was distilled off to provide 1.48 g of the title compound.

Workup

  1. customthe reaction liquid
  2. customThe reaction liquid
  3. filtrationwas filtered through Celite and from the filtrate the solvent
  4. distillationwas distilled off

Sources & evidence

ORD record
ord-b5c0ac0909824c4593c5534b37e59c71
Source dataset
uspto-grants-2015_05
Patent number
US09040536B2

Reaction notes

Loading…