反应详情

Ethyl(E)-3-(4-oxo-7-trifluoromethyl-4,5-dihydropyrrolo[1,2-a]-quinoxalin-1-yl)acrylate as synthesized in Example 188, 182 mg, 5% palladium carbon 80 mg and acetic acid 6 mL were mixed and stirred under hydrogen atmosphere at room temperature for 16 hours. Filtering the reaction liquid through Celite, 50 mL of water was added to the filtrate and the precipitated crystals were recovered by filtration. The crystals were washed successively with water and diethyl ether, and dried in flowing air under heating to provide 120 mg of the title compound.

1. additionwere mixed
2. filtrationFiltering
3. customthe reaction liquid through Celite, 50 mL of water
4. additionwas added to the filtrate
5. filtrationthe precipitated crystals were recovered by filtration
6. washThe crystals were washed successively with water and diethyl ether
7. customdried
8. temperatureunder heating