Sulfuric Acid → 1-(4-Fluoro-2-methoxy-5-nitrophenyl)ethanone

HRID 576855Notes

Reaction equation

HRID 576855 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([O:16][CH3:17])[CH:8]=1.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[F:6][C:7]1[C:12]([N+:18]([O-:20])=[O:19])=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([O:16][CH3:17])[CH:8]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 1428871-(4-Fluoro-2-methoxyphenyl)ethan-1-one

Product 1

HCID 591989251-(4-Fluoro-2-methoxy-5-nitrophenyl)ethanoneYield 92.8%

Procedure

In nitrogen atmosphere, conc. sulfuric acid 36 mL was added to 1-(4-fluoro-2-methoxyphenyl)ethanone 5.50 g, followed by heating to homogeneity. Cooling the same with salt-ice, potassium nitrate 3.47 g was added little by little, followed by an hour's stirring. The reaction liquid was poured in ice water, and the precipitated crystals were recovered by filtration and washed with water. Drying the crystals, 6.47 g of the title compound was obtained.

Workup

  1. temperatureby heating to homogeneity
  2. additionwas added little by little,
  3. waitfollowed by an hour
  4. customThe reaction liquid
  5. filtrationthe precipitated crystals were recovered by filtration
  6. washwashed with water
  7. customDrying the crystals

Sources & evidence

ORD record
ord-c4e26dee86bc479dbd4c1589649fa146
Source dataset
uspto-grants-2015_05
Patent number
US09040536B2

Reaction notes

Loading…