HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 3-[1-(4-fluoro-2-nitrophenyl)-1H-imidazol-2-yl]-propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | Ethyl 3-(1H-imidazol-2-YL)propanoate | HCID 22259341 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 3-[1-(4-fluoro-2-nitrophenyl)-1H-imidazol-2-yl]-propanoate | HCID 59198877 | 47.8% |
Reaction Steps
1,4-Difluoro-2-nitrobenzene 239 mg, ethyl 3-(1H-imidazol-2-yl)propanoate 252 mg, potassium carbonate 415 mg and N,N-dimethylacetamide 10 mL were heated at 100° C. for 64 hours. The reaction liquid was diluted with ethyl acetate and filtered. The filtrate was condensed under reduced pressure and subjected to silica gel chromatography (ethyl acetate) to provide 220 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040536B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-136d36b5f47a47d9b53fb68fb3c7ca1d |
| Source note | uspto-grants-2015_05 |