2-(Bromomethyl)-1,3-difluorobenzene → HCID 178429485, compound

HRID 576914Notes

Reaction equation

HRID 576914 reaction equation
Br[CH2:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[F:10].[CH3:11][C:12]1[N:17]=[C:16]([SH:18])[N:15]=[C:14]([OH:19])[CH:13]=1>>[F:10][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([F:9])[C:3]=1[CH2:2][S:18][C:16]1[N:15]=[C:14]([OH:19])[CH:13]=[C:12]([CH3:11])[N:17]=1

Participants

3

Reactant 2

HCID 5814352-(Bromomethyl)-1,3-difluorobenzeneHCID 178429541HCID 178429541, compound

Product 1

HCID 178429485HCID 178429485, compoundYield 79%

Procedure

As per procedure from Example 1, the title compound was prepared from 2-(bromomethyl)-1,3-difluorobenzene and 6-methyl-2-sulfanylpyrimidin-4-ol to provide the title compound as a white solid (1.02 g, 79% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.04 (s, 3H), 4.42 (s, 2H), 6.01 (bs, 1H), 7.12 (m, 2H), 7.38 (m, 1H), 12.29 (2 bs); M+ 268.8.

Sources & evidence

ORD record
ord-a0d67f41beb04c14b416313799efa8d4
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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