反应详情

(2-chloro-4-nitrophenyl)methanol (707 mg, 3.73 mmol) was dissolved in dichloromethane (15 mL) at 0° C. under nitrogen. Tribromophosphane (0.7 mL, 7.46 mmol) was added dropwise. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by addition of 10% NaHCO3 solution (2 mL). After 10 minutes, Na2SO4 (15 g) was added. The solvent was filtered and evaporated to provide 1-(bromomethyl)-2-chloro-4-nitrobenzene, which was used without further purification.

1. customThe reaction was quenched by addition of 10% NaHCO3 solution (2 mL)
2. waitAfter 10 minutes
3. additionNa2SO4 (15 g) was added
4. filtrationThe solvent was filtered
5. customevaporated