反应详情

Quinolin-3-ylmethanol was dissolved dichloromethane (15 mL) at 0° C. under nitrogen. Tribromophosphane (2.15 mL, 22 mmol) was added dropwise. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by addition of 10% NaHCO3 solution (5 mL). After 10 minutes, Na2SO4 (30 g) was added. The solvent was filtered and evaporated to provide 3-(bromomethyl)quinoline, which was used without further purification.

1. customThe reaction was quenched by addition of 10% NaHCO3 solution (5 mL)
2. waitAfter 10 minutes
3. additionNa2SO4 (30 g) was added
4. filtrationThe solvent was filtered
5. customevaporated