1,4-Dioxane hydrochloride → HCID 178429498, compound

HRID 576983Notes

Reaction equation

HRID 576983 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9][C:10]2[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=2)[CH:5]=[N:6][CH:7]=1.[ClH:18].O1CCOCC1>CO>[ClH:18].[F:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9][C:10]2[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=2)[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178429497HCID 178429497, compound

Product 1

HCID 178429498HCID 178429498, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 2-{[(5-fluoropyridin-3-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (185 mg, 0.74 mmol) in MeOH (2 mL) was added 4 M HCl/dioxane (1 mL, 4.0 mmol). The mixture was evaporated and dried in vacuo, affording the title compound (213 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.22 (s, 3H), 4.43 (s, 2H), 6.09 (s, 1H), 7.96 (td, 1H, J=2.7 Hz, 7.4 Hz), 8.57 (d, 1H, J=2.5 Hz), 8.62 (t, 1H, J=1.6 Hz); M+ 252.

Workup

  1. customThe mixture was evaporated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-c5856e4b66c140f38438f161654f6501
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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