HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (1-methyl-1H-1,3-benzodiazol-2-yl)methanol | HCID 344177 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide | HCID 24229451 | — |
Reaction Steps
To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040538B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-57f3301b836a4bb08298525512a33331 |
| Source note | uspto-grants-2015_05 |