Acetic Anhydride → HCID 19794108, compound

HRID 5770Notes

Reaction equation

HRID 5770 reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH2:4][NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][C:7]1([CH3:17])[CH3:16].[C:19](OC(=O)C)(=[O:21])C>C(O)=O>[CH3:1][O:2][C:3](=[O:18])[CH2:4][N:5]([CH:19]=[O:21])[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][C:7]1([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19794110Methyl N-(2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)glycinate

Product 1

HCID 19794108HCID 19794108, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The complete yield of N-(2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)glycine methyl ester of the process a) is added dropwise with cooling to 5° C. to 67.8 ml of formic acid. Additionally 24.9 ml of acetic anhydride are added, and the mixture is kept at room temperature for 70 hours. Destillation under vacuum affords 35.2 g of N-formyl-N-(2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)glycine methyl ester having a melting point of 74°-75° C.

Sources & evidence

ORD record
ord-16ccefa01c1e42bcac9d0c141776cc38
Source dataset
uspto-grants-1993_09
Patent number
US05246915

Reaction notes

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