HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-2-(piperidin-3-ylamino)-1,3-thiazole-5-carbonitrile dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]piperidine-1-carboxylate | HCID 57911784 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Amino-2-(piperidin-3-ylamino)-1,3-thiazole-5-carbonitrile dihydrochloride | HCID 86635022 | — |
Reaction Steps
Analogously to the preparation of Example 38A, 240 mg (0.7 mmol) of tert-butyl 3-[(4-amino-5-cyano-1,3-thiazol-2-yl)-amino]piperidine-1-carboxylate (Example 46A) and 25 ml of hydrochloric acid in dioxane (4M) gave 265 mg (57% of theory) of the product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434731B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b4129fad430846698a2eec5f053afff6 |
| Source note | uspto-grants-2016_09 |