反应详情

2.775 g (4.52 mmol) of Oxone were dissolved in 9 ml of water, and 500 mg (2.66 mmol) of 1-[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]ethanone, dissolved in 9 ml of methanol, were added dropwise at 5° C. The mixture was stirred at RT for 3 h, the methanol was reduced on a rotary evaporator and the residue was extracted twice with dichloromethane. Removal of the solvent gave 395 mg (52% of theory) of the product as a solid.

1. additionwere added dropwise at 5° C
2. customthe methanol was reduced on a rotary evaporator
3. extractionthe residue was extracted twice with dichloromethane
4. customRemoval of the solvent