Methanol → HCID 58170002, compound

HRID 57701Notes

Reaction equation

HRID 57701 reaction equation
O[O:2][S:3]([O-:5])=O.[K+].[NH2:7][C:8]1[N:9]=[C:10](SC)[S:11][C:12]=1[C:13](=[O:15])[CH3:14].[CH3:18]O>O>[NH2:7][C:8]1[N:9]=[C:10]([S:3]([CH3:18])(=[O:5])=[O:2])[S:11][C:12]=1[C:13](=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 887MethanolHCID 8167111-[4-Amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]ethan-1-oneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 58170002HCID 58170002, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.775 g (4.52 mmol) of Oxone were dissolved in 9 ml of water, and 500 mg (2.66 mmol) of 1-[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]ethanone, dissolved in 9 ml of methanol, were added dropwise at 5° C. The mixture was stirred at RT for 3 h, the methanol was reduced on a rotary evaporator and the residue was extracted twice with dichloromethane. Removal of the solvent gave 395 mg (52% of theory) of the product as a solid.

Workup

  1. additionwere added dropwise at 5° C
  2. customthe methanol was reduced on a rotary evaporator
  3. extractionthe residue was extracted twice with dichloromethane
  4. customRemoval of the solvent

Sources & evidence

ORD record
ord-4fd7e252225341a388491c2f5a97e2ad
Source dataset
uspto-grants-2016_09
Patent number
US09434731B2

Reaction notes

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