反应详情

To a solution of 2-chloroquinoline-3-carbaldehyde (1.0 g, 5.21 mmol) in anhydrous ethanol (20 mL) at 0° C., was added sodium borohydride (0.197 g, 5.21 mmol). The reaction mixture was stirred at the same temperature for 1 hour. After completion of the reaction, as monitored by TLC and HPLC, the reaction mixture was quenched with water. The solvent was evaporated, and the crude residue was extracted with dichloromethane. The organic layer was washed with water and brine and dried over anhydrous sodium sulfate to provide the (2-chloroquinolin-3-yl)methanol as a white solid (0.96 g, 95% yield); M+ 193.64.

1. customAfter completion of the reaction
2. customthe reaction mixture was quenched with water
3. customThe solvent was evaporated
4. extractionthe crude residue was extracted with dichloromethane
5. washThe organic layer was washed with water and brine
6. dry with materialdried over anhydrous sodium sulfate