Sodium borohydride → HCID 23330426, compound

HRID 577030Notes

Reaction equation

HRID 577030 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH3:17])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH2:15]2)[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 595894762-Chloro-4-(4-ethylpiperazin-1-yl)benzaldehyde

Product 1

HCID 23330426HCID 23330426, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

The crude 2-chloro-4-(4-ethylpiperazin-1-yl)benzaldehyde was dissolved in anhydrous ethanol (20 mL). The solution was cooled to 0° C. under nitrogen, and NaBH4 (1.52 g, 40 mmol) was added in one portion. The mixture was stirred at room temperature for 2 hours and quenched by addition of water (5 mL). Na2SO4 (20 g) was then added. After 10 minutes, the mixture was filtered. The filtrate was evaporated to provide [2-chloro-4-(4-ethylpiperazin-1-yl)phenyl]methanol.

Workup

  1. customquenched by addition of water (5 mL)
  2. additionNa2SO4 (20 g) was then added
  3. waitAfter 10 minutes
  4. filtrationthe mixture was filtered
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-7f10f136c52d4149a10175ad5f70bbb7
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

Loading…