1,4-Dioxane hydrochloride → HCID 178429535, compound

HRID 577067Notes

Reaction equation

HRID 577067 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[S:14][CH:13]=[N:12][C:11]=2[CH3:15])[N:5]=[C:4]([OH:16])[CH:3]=1.[ClH:17].O1CCOCC1>CO>[ClH:17].[CH3:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[S:14][CH:13]=[N:12][C:11]=2[CH3:15])[N:5]=[C:4]([OH:16])[CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178429534HCID 178429534, compound

Product 1

HCID 178429535HCID 178429535, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 6-methyl-2-{[(4-methyl-1,3-thiazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol (500 mg, 2.0 mmol) in MeOH (5 mL) was added 4 M HCl/dioxane (2 mL, 8.0 mmol). The solution was evaporated and dried in vacuo, affording the title compound (213 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.26 (s, 3H), 2.44 (s, 3H), 4.58 (s, 2H), 6.08 (s, 1H), 9.10 (s, 1H); M+ 254.

Workup

  1. customThe solution was evaporated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-4d485c56024446bfaad78e4b51f37b61
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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