1,4-Dioxane hydrochloride → 2-[(5-chloro-1-methylimidazol-4-yl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-one;hydrochloride

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Reaction Steps

To a mixture of 2-{[(5-chloro-1-methyl-1H-imidazol-4-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (50 mg, 0.18 mmol) in MeOH (2 mL) was added 4 M HCl/dioxane (500 μL, 2.0 mmol). The solution was evaporated and dried in vacuo, affording the title compound (55 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.23 (s, 3H), 3.75 (s, 3H), 4.45 (s, 2H), 6.08 (s, 1H), 9.13 (s, 1H); M+ 271.

Provenance & Evidence