Phosphorus tribromide → 4-(Bromomethyl)-3-chloro-5-ethylpyridine

Participants

Reaction Steps

To a solution of (3-chloro-5-ethylpyridin-4-yl)methanol (1.83 g, 10.66 mmol) in anhydrous chloroform (40 mL) was added dropwise tribromophosphane (2.91 g, 1.01 mL, 10.75 mmol) at 0° C. The reaction mixture was allowed to stir overnight at room temperature. The solvent was evaporated to provide crude 4-(bromomethyl)-3-chloro-5-ethylpyridine, which was used in the next step without further purification.

Provenance & Evidence