HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-formyl-N-(2,2-dimethyl-indan-1-yl)glycine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N-(2,2-dimethyl-indan-1-yl)glycine methyl ester | HCID 19794085 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | N-formyl-N-(2,2-dimethyl-indan-1-yl)glycine methyl ester | HCID 19794078 | — |
Reaction Steps
936 g of N-(2,2-dimethyl-indan-1-yl)glycine methyl ester are added dropwise with cooling to 5° C. to 1817 ml of formic acid. Additionally 664 ml of acetic anhydride are added, and the mixture is kept at room temperature for 18.5 hours. Destillation under vacuum affords 1015 g of N-formyl-N-(2,2-dimethyl-indan-1-yl)glycine methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246915 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-90f241a6026441e4b5bbd36ef857d8ed |
| Source note | uspto-grants-1993_09 |