Phosphorus tribromide → HCID 59589453, compound

HRID 577113Notes

Reaction equation

HRID 577113 reaction equation
[Cl:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH2:11]O.[Br:13]P(Br)Br>C(Cl)(Cl)Cl>[Br:13][CH2:11][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[C:2]=1[Cl:1]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 59589432HCID 59589432, compound

Product 1

HCID 59589453HCID 59589453, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of {3-chloroimidazo[1,2-a]pyridin-2-yl}methanol (0.799 g, 4.39 mmol) in anhydrous chloroform (25 mL) at 0° C. was added tribromophosphane (1.20 g, 0.41 mL, 4.43 mmol), and the reaction mixture was allowed to stir at room temperature overnight. The solvent was evaporated to provide the crude 2-(bromomethyl)-3-chloroimidazo[1,2-a]pyridine, which was used for the next step without any further purification; M+1 246.2.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-ddcdea4451c1481ebadbe6af1592b18d
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

Loading…