Hydrochloric Acid → HCID 178463039, compound

Participants

Reaction Steps

2-{[(1-ethyl-1H-pyrazol-5-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (150 mg, 600 μmol) was stirred in methanol (20 mL) and a solution of 4 N HCl in dioxane (225 μL, 900 μmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(1-ethyl-1H-pyrazol-5-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride (170 mg, 100% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.30 (t, J=7.0 Hz, 3H), 2.21 (s, 3H), 4.15 (q, J=7.0 Hz, 2H), 4.50 (s, 2H), 6.11 (s, 1H), 6.25 (d, J=1.7 Hz, 1H), 7.37 (d, J=1.7 Hz, 1H); LRMS (ES+) m/z 251 (50%, M+1).

Provenance & Evidence