Hydrochloric Acid → HCID 178429458, compound

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Reaction Steps

2-({[4-chloro-2-(propan-2-yl)pyridin-3-yl]methyl}sulfanyl)-6-methylpyrimidin-4-ol (176 mg, 570 μmol) was stirred in methanol (20 mL), and a solution of 4 N HCl in dioxane (215 μL, 855 μmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-({[4-chloro-2-(propan-2-yl)pyridin-3-yl]methyl}sulfanyl)-6-methylpyrimidin-4-ol hydrochloride (200 mg, 100% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.28 (d, J=6.7 Hz, 6H), 2.26 (s, 3H), 3.56-3.68 (m, 1H), 4.70 (s, 2H), 6.14 (s, 1H), 7.69 (d, J=5.5 Hz, 1H), 8.55 (d, J=5.5 Hz, 1H); LRMS (ES+) m/z 310 (15%, M+1).

Provenance & Evidence