反应详情

2-{[(4-chloro-1-methyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol (120 mg, 370 μmol) was stirred in methanol (15 mL) and a solution of 4 N HCl in dioxane (140 μL, 554 μmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(4-chloro-1-methyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride (85 mg, 63% yield); 1H NMR (400 MHz, DMSO-d6): δ 3.78 (s, 3H), 4.39 (s, 2H), 6.66 (s, 1H), 7.94 (s, 1H); LRMS (ES+) m/z 325 (10%, M+1).

1. customThe solvent was removed by evaporation
2. customthe residue was triturated with diethyl ether
3. customdried in vacuo