Hydrochloric Acid → 2-[(4-chloro-2-ethyl-3-pyridinyl)methylsulfanyl]-6-(trifluoromethyl)-1H-pyrimidin-4-one;hydrochloride

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Reaction Steps

2-{[(4-chloro-2-ethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol (165 mg, 472 μmol) was stirred in methanol (20 mL) and a solution of 4 N HCl in dioxane (180 μL, 708 μmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(4-chloro-2-ethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride (160 mg, 88% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.21 (t, J=7.4 Hz, 3H), 3.05 (q, J=7.4 Hz, 2H), 4.69 (s, 2H), 6.71 (s, 1H), 7.71 (d, J=5.7 Hz, 1H), 8.53 (d, J=5.7 Hz, 1H); LRMS (ES+) m/z 350 (100%, M+1).

Provenance & Evidence