Hydrochloric Acid → HCID 178437598, compound

Participants

Reaction Steps

2-{[(2-ethylpyridin-3-yl)methyl]sulfanyl)-6-(trifluoromethyl)pyrimidin-4-ol (218 mg, 694 μmol) was stirred in methanol (30 mL), and a solution of 4 N HCl in dioxane (260 μL, 1.04 mmol) was dropwise added at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(2-ethylpyridin-3-yl)methyl]sulfanyl)-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride (225 mg, 92% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.28 (t, J=7.6 Hz, 3H), 3.11-3.17 (m, 2H), 4.58 (s, 2H), 6.65 (s, 1H), 7.77 (q, J=5.9 Hz, J=1.8 Hz, 1H), 8.49 (d, J=7.8 Hz, 1H), 8.39 (d, J=5.5 Hz 1H).

Provenance & Evidence