反应详情

2-{[(2,4-diethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol (500 mg, 1.5 mmol) was stirred in methanol (60 mL), and a solution of 4 N HCl in dioxane (550 μL, 2.2 mmol) was added dropwise at 0° C. The mixture was stirred for 10 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(2,4-diethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride (530 mg, 95% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.21-1.29 (m, 6H), 2.93 (q, J=7.5 Hz, 2H), 3.11-3.17 (m, 2H), 4.69 (s, 2H), 6.74 (s, 1H), 7.79 (d, J=6.1 Hz, 1H), 8.65 (d, J=6.1 Hz, 1H); LRMS (ES+) m/z 344 (100%, M+1).

1. customThe solvent was removed by evaporation
2. customthe residue was triturated with diethyl ether
3. customdried in vacuo