Hydrochloric Acid → HCID 178429494, compound

Participants

Reaction Steps

6-methyl-2-({[4-(trifluoromethyl)pyridin-3-yl]methyl}sulfanyl)pyrimidin-4-ol, (150 mg, 498 μmol) was stirred in methanol (20 mL) and a solution of 4 N HCl in dioxane (190 μL, 747 μmol) was added dropwise at 0° C. The mixture was stirred for 15 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 6-methyl-2-({[4-(trifluoromethyl)pyridin-3-yl]methyl}sulfanyl)pyrimidin-4-ol hydrochloride (147 mg, 88% yield); 1H NMR (400 MHz, DMSO-d6) δ 2.23 (s, 3H), 4.60 (s, 2H), 6.11 (s, 1H), 7.78 (d, J=5.1 Hz, 1H), 8.78 (d, J=5.1 Hz, 1H), 9.04 (s, 1H); LRMS (ES+) m/z 302 (100%, M+1).

Provenance & Evidence