Phosphorus tribromide → HCID 59589454, compound

HRID 577204Notes

Reaction equation

HRID 577204 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([CH2:15]O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[Br:17]P(Br)Br>C(Cl)(Cl)Cl>[Br:17][CH2:15][C:12]1[CH:11]=[CH:10][C:9]([N:6]2[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]2)=[N:14][CH:13]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 59589479HCID 59589479, compound

Product 1

HCID 59589454HCID 59589454, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of [6-(4-ethylpiperazin-1-yl)pyridin-3-yl]methanol (3.0 g, 13.55 mmol) in anhydrous chloroform was added at 0° C. tribromophosphane (4.03 g, 14.91 mmol). The reaction mixture was allowed to stir at room temperature for 3 hours. The solvent was evaporated to provide 1-[5-(bromomethyl)pyridin-2-yl]-4-ethylpiperazine (3.85 g), which was used in the next step without any further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-908ded64670f4a4f98752e44edafa8d5
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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