HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57721Generated: October 25, 2026
Ammonium Hydroxide → 1-[[2-(Phenylmethoxy)acetyl]amino]-1H-imidazole-5-carboxamide
https://huagongshe.com/reaction/57721
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-(2-Benzyloxy-acetylamino)-3H-imidazole-4-carboxylic acid methyl ester | HCID 89715196 | — |
| Product | 1-[[2-(Phenylmethoxy)acetyl]amino]-1H-imidazole-5-carboxamide | HCID 89714812 | 88% |
Reaction Steps
Compound 2 (8.7 g, 30.1 mmol) and ammonium hydroxide (15 ml) were combined in a sealed tube and heated to 70° C. under microwave irradiation for 2 hours. The mixture was concentrated in vacuo to afford compound 3 (7.3 g, 88% yield) as a white solid. LC-MS: m/z 275.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434733B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-c9d80954d63d4e63b59351e0de4a8653 |
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| Source note | uspto-grants-2016_09 |
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