Phosphorus tribromide → HCID 59589374, compound

HRID 577211Notes

Reaction equation

HRID 577211 reaction equation
[CH2:1]([C:3]1[C:7]([CH2:8]O)=[C:6]([CH2:10][CH3:11])[O:5][N:4]=1)[CH3:2].[Br:12]P(Br)Br>C(Cl)Cl>[Br:12][CH2:8][C:7]1[C:3]([CH2:1][CH3:2])=[N:4][O:5][C:6]=1[CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 59589390HCID 59589390, compound

Product 1

HCID 59589374HCID 59589374, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3,5-diethyl-1,2-oxazol-4-yl)methanol (710 mg, 4.6 mmol) in anhydrous DCM (30 mL) was added tribromophosphane (465 μL, 4.9 mmol). The mixture was stirred at room temperature for 5 hours, and then DCM was evaporated. The residue was dried in vacuo, affording 4-(bromomethyl)-3,5-diethyl-1,2-oxazole, which was used without further purification.

Workup

  1. customDCM was evaporated
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-39c3d967e87a448e879102070d1ca6a5
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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