1,4-Dioxane hydrochloride → HCID 178429451, compound

HRID 577240Notes

Reaction equation

HRID 577240 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH3:18])[C:7]=1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1.[ClH:19].O1CCOCC1>CO>[ClH:19].[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH3:18])[C:7]=1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178429450HCID 178429450, compound

Product 1

HCID 178429451HCID 178429451, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 0° C. mixture of 2-{[(3,5-dimethylpyridin-4-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (1.1 g, 3.8 mmol) in MeOH (15 mL) was added 4M HCl/dioxane (4 mL, 16 mmol). The solution was evaporated and dried in vacuo, affording the title compound (1.1 g, 97% yield); 1H NMR (500 MHz, DMSO-d6): δ 2.23 (s, 3H), 2.56 (s, 6H), 4.65 (m, 2H), 4.44 (s, 2H), 6.15 (s, 1H), 8.69 (s, 1H); M+ 262.

Workup

  1. customThe solution was evaporated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-95f305156b7742299e93ccd15a37c8a3
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

Loading…