Dimethylamine → HCID 66765443, compound

HRID 577282Notes

Reaction equation

HRID 577282 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH:10]2[CH2:12][O:11]2)[CH:8]=1)([O-:3])=[O:2].[CH3:13][NH:14][CH3:15]>>[CH3:13][N:14]([CH3:15])[CH2:12][CH:10]([OH:11])[CH2:9][N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[N:6]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 43185732HCID 43185732, compound

Product 1

HCID 66765443HCID 66765443, compound

Procedure

4-nitro-1-(oxiran-2-ylmethyl)-1H-pyrazole (200 mg, 1.2 mmol) was stirred overnight at rt in dimethylamine (2M in methanol, 5 mL). The solution was concentrated to give 1-(dimethylamino)-3-(4-nitro-1H-pyrazol-1-yl)propan-2-ol as a yellow solid (quantitative). LC-MS (UPLC, high pH), (ES+) 215.2, RT=0.75 min.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-05a10d0c125b4c81bc23fc23fb5f6e1e
Source dataset
uspto-grants-2015_05
Patent number
US09040545B2

Reaction notes

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