HCID 66765443, compound → HCID 43369894, compound

HRID 577283Notes

Reaction equation

HRID 577283 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH:4]([OH:14])[CH2:5][N:6]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[N:7]1.[H][H]>[Pd].C(O)C>[NH2:11][C:9]1[CH:8]=[N:7][N:6]([CH2:5][CH:4]([OH:14])[CH2:3][N:2]([CH3:1])[CH3:15])[CH:10]=1

Participants

5

Reactant 2

HCID 66765443HCID 66765443, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 43369894HCID 43369894, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(dimethylamino)-3-(4-nitro-1H-pyrazol-1-yl)propan-2-ol (253 mg, 1.18 mmol) and palladium on carbon (10%, 25 mg) were stirred in ethanol (5 mL) under a balloon of hydrogen for 24 h. The palladium was removed by filtration through celite and the solution was concentrated to afford 1-(4-amino-1H-pyrazol-1-yl)-3-(dimethylamino)propan-2-ol as a brown oil (200 mg), which was used crude in the following reaction.

Workup

  1. customThe palladium was removed by filtration through celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-b695584ae36c4b77a9ac9e55ed2eca54
Source dataset
uspto-grants-2015_05
Patent number
US09040545B2

Reaction notes

Loading…