tert-Butyl piperazine-1-carboxylate → HCID 66765419, compound

HRID 577292Notes

Reaction equation

HRID 577292 reaction equation
Br[C:2]1[CH:3]=[C:4]([F:12])[C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[N:13]1([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[C:22]([O:21][C:19]([N:13]1[CH2:18][CH2:17][N:16]([C:2]2[CH:3]=[C:4]([F:12])[C:5]([F:11])=[C:6]([CH:10]=2)[C:7]([OH:9])=[O:8])[CH2:15][CH2:14]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 230017945-Bromo-2,3-difluorobenzoic acid

Product 1

HCID 66765419HCID 66765419, compound

Procedure

5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2,3-difluorobenzoic acid was prepared as in Example 2 (Step ii) using 5-bromo-2,3-difluorobenzoic acid and tert-butyl piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-6cae7eb4e2f94c84bfe026db08a558c3
Source dataset
uspto-grants-2015_05
Patent number
US09040545B2

Reaction notes

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