HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| Reactant | tert-Butyl 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate | HCID 11049999 | — |
| Product | 7-Benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride | HCID 17973220 | 91% |
Reaction Steps
Using an analogous procedure to that described in Example 6,7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (1.55 g, 5.15 mmol), (prepared, for example, as described in WO 97/22596, Example 1), was reacted with 2-fluoro-4-methylaniline (700 mg, 5.67 mmol) in isopropanol (90 ml) containing 6.2M hydrogen chloride in isopropanol (80 μl, 0.51 mmol) to give 7-benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride (2 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040548B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-b634506363914e328901883385880c98 |
| Source note | uspto-grants-2015_05 |