HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetic acid → N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)-2-cyanoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 4-(3-aminophenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine | HCID 24989921 | — |
| Product | N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)-2-cyanoacetamide | HCID 24989919 | 65.5% |
Reaction Steps
In a procedure analogous to Example 15, reaction of 4-(3-aminophenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (50 mg, 0.13 mmol) and cyanoacetic acid (23 mg, 0.26 mmol) furnished the product (38 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040549B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-7fcfb379f94c44dab78b3b23420c7608 |
| Source note | uspto-grants-2015_05 |