Acrylic Acid → N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide

HRID 577411Notes

Reaction equation

HRID 577411 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[C:11]([NH2:15])[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[C:16](O)(=[O:19])[CH:17]=[CH2:18]>>[Cl:1][C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:19])[CH:17]=[CH2:18])[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 866455733-(2-Chloropyrimidin-4-ylthio)benzenamine

Product 1

HCID 86645569N-(3-(2-chloropyrimidin-4-ylthio)phenyl)acrylamideYield 68%

Procedure

In a procedure analogous to Example 15, reaction of 3-(2-chloropyrimidin-4-ylthio)benzenamine (300 mg, 1.26 mmol) and acrylic acid (173 μL, 2.52 mmol) furnished the product (250 mg, 68%).

Sources & evidence

ORD record
ord-e23fbdfd87c44c29b765e6a30099823b
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Reaction notes

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