Acrylic Acid → HCID 59491541, compound

HRID 577413Notes

Reaction equation

HRID 577413 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[N:11]=2)=[CH:5][CH:4]=1.[C:24](O)(=[O:27])[CH:25]=[CH2:26]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([S:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:27])[CH:25]=[CH2:26])=[CH:19][CH:18]=3)[N:11]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 59491773HCID 59491773, compound

Product 1

HCID 59491541HCID 59491541, compoundYield 55.1%

Procedure

In a procedure analogous to Example 15, reaction of N1-(4-(4-methoxyphenylthio)pyrimidin-2-yl)benzene-1,4-diamine (80 mg, 0.23 mmol) and acrylic acid (24 μL, 0.46 mmol) furnished the product (48 mg, 55%).

Sources & evidence

ORD record
ord-2fef0edbdf7343818e847692c0c4fa2f
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Reaction notes

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