Acrylic Acid → HCID 59491512, compound

HRID 577416Notes

Reaction equation

HRID 577416 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:11]=2)[CH:6]=[CH:7][CH:8]=1.[C:29](O)(=[O:32])[CH:30]=[CH2:31]>>[O:26]1[CH2:25][CH2:24][N:23]([C:20]2[CH:19]=[CH:18][C:17]([NH:16][C:12]3[N:11]=[C:10]([S:9][C:5]4[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=4)[CH2:2][NH:1][C:29](=[O:32])[CH:30]=[CH2:31])[CH:15]=[CH:14][N:13]=3)=[CH:22][CH:21]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 59491530HCID 59491530, compound

Product 1

HCID 59491512HCID 59491512, compoundYield 31.3%

Procedure

In a procedure analogous to Example 15, reaction of 4-(3-(aminomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (60 mg, 0.15 mmol) and acrylic acid (16 mg, 0.23 mmol) furnished the product (21 mg, 31%).

Sources & evidence

ORD record
ord-a93d9f09789e4a6bb60297fffa6766e2
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Reaction notes

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