HuagongsheHuagongshe Chemistry Print Report · For research reference only
Binap, (A+-)- → HCID 72705994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 67548813 | HCID 67548813 | — |
| Reactant | HCID 72705803 | HCID 72705803 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 72705994 | HCID 72705994 | — |
Reaction Steps
The title compound was prepared in the same procedure as described in Example 3-(((1R,2S)-2-aminocyclohexyl)amino)-5-(pyridin-3-ylamino)-1,2,4-triazine-6-carboxamide. However, here Pd(OAc)2 and BINAP were substituted for Pd2(dba)3 and Xantphos. Additionally, dioxane was used as the solvent. The coupling partner, 4-iodo-1-methyl-1H-pyrazolo[3,4-b]pyridine, was synthesized as seen below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040530B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a330a4137b5a4f93b27d0714c75cf61b |
| Source note | uspto-grants-2015_05 |