反应详情

温度

50 °C

To a solution of methyl 1-oxo-7-(propan-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-5-carboxylate (Cpd E, 1.00 g, 3.80 mmol) in MeOH (20 mL) was added NaOH (3.00 mL, 12.0 mmol). The resulting reaction mixture was stirred at 50° C. for 3 hours. Volatiles were removed under vacuum and the resulting residue was dissolved in MeOH (30 mL), and neutralized with 1 M HCl to pH=2˜3. Precipitates were formed, collected by filtration, washed with water, and dried in an oven at 60° C. under vacuum to give 1-oxo-7-(propan-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid (77a, 918 mg, 97%) as a white solid.

1. customThe resulting reaction mixture
2. customVolatiles were removed under vacuum
3. dissolutionthe resulting residue was dissolved in MeOH (30 mL)
4. customPrecipitates
5. customwere formed
6. filtrationcollected by filtration
7. washwashed with water
8. customdried in an oven at 60° C. under vacuum