HCID 86723767, compound → HCID 86723768, compound

Participants

Reaction Steps

A mixture of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-methyl-5-(1-methyl-1H-pyrazol-4-yl)-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one (108k, 40 mg, 0.076 mmol) and 10% Pd/C (20 mg) in MeOH (10 mL) was hydrogenated under an H2 balloon at room temperature for 16 hours. The reaction mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by prep. TLC (EtOAc) to give the title compound (Example 108, 19 mg, 58%) as a white solid. 1H NMR (400 MHz, methanol-d4) δ 7.72 (s, 1H), 7.56 (s, 1H), 7.03 (s, 1H), 6.11 (s, 1H), 4.78 (s, 3H), 4.6-4.57 (m, 1H), 3.92 (s, 3H), 3.92 (s, 3H), 2.82-2.81 (m, 2H), 2.47 (s, 3H), 2.28-2.24 (m, 5H), 1.34-1.32 (d, 6H); MS 435.2 [M+H].

Provenance & Evidence