Trifluoroacetic acid → HCID 86679620, compound

Participants

Reaction Steps

To a solution of the TFA salt of N-(1-methyl-1H-pyrazol-4-yl)-4-{[trans-4-methylpyrrolidin-3-yl]methoxy}-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-2-amine (0.9 g, 1.61 mmol) in dry DCM (20 mL) were added DIPEA (1.25 g, 9.7 mmol) and acryloyl chloride (144.9 mg, 1.61 mmol) at rt. After the addition, the reaction mixture was stirred at rt for 1 hr. TLC(CH2Cl2/MeOH=10:1) showed the reaction was complete. The reaction mixture was diluted with DCM (10 mL), washed with water (10 mL), brine (10 mL), dried over Na2SO4 and concentrated to yield the title compound (0.82 g, 100% yield) as a brown solid.

Provenance & Evidence