Water → HCID 178484864, compound

Participants

Reaction Steps

To a solution of tert-butyl methyl{trans-3-[(2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-(pyridin-3-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]cyclobutyl}carbamate (250 mg, 0.4 mmol) in DCM (10 mL) was added TFA (0.33 mL). The reaction solution was stirred at ambient temperature for 20 hrs. The volatiles were removed in vacuo to give a residue, which was dissolved in methanol (8 mL). Water (4 mL) and solid K2CO3 (223 mg) were added, and the mixture was stirred at ambient temperature for 2 hrs. The volatiles were then removed in vacuo to give the title compound that was used as crude in the next step.

Provenance & Evidence