HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577743Generated: November 1, 2026
Ethyl Acetate → (3-Methyl-4-nitro-1H-pyrazol-1-YL)acetonitrile
https://huagongshe.com/reaction/577743
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | HCID 178434564 | HCID 178434564 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (3-Methyl-4-nitro-1H-pyrazol-1-YL)acetonitrile | HCID 19620685 | 38.3% |
Reaction Steps
A mixture of 3-methyl-4-nitro-1H-pyrazole (7 g, 0.055 mol), bromoacetonitrile (13.2 g, 0.11 mol) and K2CO3 (23 g, 0.165 mol) in DMF (120 mL) was stirred at 80° C. for 2 hrs. TLC (petroleum ether:EtOAc=2:1) showed the reaction was complete. The mixture was filtered, concentrated and the residue purified by flash chromatography (petroleum ether:EtOAc=4:1) to give the title compound (3.5 g, 38% yield) as light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09040547B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-9963224fe4c54c54980093792cbabddb |
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| Source note | uspto-grants-2015_05 |
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